Bruce S Klein Selected Research

Blastomycosis

1/2019	Investigation of Genetic Susceptibility to Blastomycosis Reveals Interleukin-6 as a Potential Susceptibility Locus.
1/2017	Blastomyces dermatitidis serine protease dipeptidyl peptidase IVA (DppIVA) cleaves ELR+ CXC chemokines altering their effects on neutrophils.
2/2014	Development of a highly sensitive and specific blastomycosis antibody enzyme immunoassay using Blastomyces dermatitidis surface protein BAD-1.
5/2011	Safety, tolerability, and immunogenicity of a recombinant, genetically engineered, live-attenuated vaccine against canine blastomycosis.
10/2005	IL-12 is required for induction but not maintenance of protective, memory responses to Blastomyces dermatitidis: implications for vaccine development in immune-deficient hosts.
6/2002	BAD1, an essential virulence factor of Blastomyces dermatitidis, suppresses host TNF-alpha production through TGF-beta-dependent and -independent mechanisms.

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Bruce S Klein Research Topics

Disease

25	Infections 01/2021 - 06/2002
18	Mycoses (Diseases, Fungus) 01/2022 - 02/2006
6	Inflammation (Inflammations) 01/2020 - 05/2011
6	Blastomycosis 01/2019 - 06/2002
4	Invasive Fungal Infections 01/2021 - 12/2002
4	Coccidioidomycosis 01/2020 - 11/2011
3	Communicable Diseases (Infectious Diseases) 01/2021 - 05/2006
3	Asthma (Bronchial Asthma) 01/2021 - 04/2013
3	Pneumonia (Pneumonitis) 01/2018 - 01/2012
2	Human Influenza (Influenza) 01/2021 - 12/2017
2	Fungal Lung Diseases 10/2018 - 12/2004
2	Histoplasmosis 04/2016 - 02/2014
2	Eosinophilia 04/2013 - 09/2012
1	Candidiasis (Moniliasis) 01/2020
1	Neoplasms (Cancer) 01/2020
1	Genetic Predisposition to Disease (Genetic Predisposition) 01/2019
1	Cryptococcosis 10/2018
1	Allergic Bronchopulmonary Aspergillosis 10/2018
1	Hyperplasia 01/2018
1	Colitis 12/2017
1	Aspergillosis 01/2017
1	Hypoxia (Hypoxemia) 01/2016
1	Hypersensitivity (Allergy) 04/2013
1	Fever (Fevers) 05/2011
1	Reinfection 05/2006

Drug/Important Bio-Agent (IBA)

23	VaccinesIBA 01/2022 - 12/2002
8	CytokinesIBA 01/2019 - 11/2005
4	Interleukin-17 (Interleukin 17)IBA 01/2021 - 05/2014
3	ChitinIBA 01/2021 - 09/2012
3	mouse dectin-2IBA 01/2021 - 02/2014
3	Pattern Recognition ReceptorsIBA 11/2018 - 02/2014
2	Fungal VaccinesIBA 01/2021 - 01/2018
2	Polysaccharides (Glycans)IBA 01/2021 - 04/2013
2	AntibodiesIBA 01/2021 - 02/2014
2	AntigensIBA 01/2021 - 01/2007
2	Fluorescent Dyes (Fluorescent Probes)IBA 01/2021 - 01/2021
2	AllergensIBA 01/2020 - 04/2013
2	Proteins (Proteins, Gene)FDA Link 01/2020 - 01/2018
2	dectin 1IBA 01/2020 - 02/2014
2	ZincIBA 12/2019 - 01/2018
2	Interleukin-5 (Interleukin 5)IBA 10/2018 - 01/2007
2	EnzymesIBA 01/2018 - 02/2014
2	Complement System Proteins (Complement)IBA 02/2014 - 04/2013
2	Virulence Factors (Pathogenicity Factors)IBA 05/2011 - 12/2004
2	Interleukin-12 (IL 12)IBA 02/2006 - 10/2005
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/2004 - 06/2002
1	Freund's AdjuvantIBA 01/2021
1	aluminum sulfate (alum)IBA 01/2021
1	Subunit VaccinesIBA 01/2021
1	Interferon-gamma (Interferon, gamma)IBA 01/2021
1	Recombinant ProteinsIBA 01/2021
1	Immunomodulating AgentsIBA 12/2020
1	Syk KinaseIBA 12/2020
1	LectinsIBA 12/2020
1	Calcium Channels (Calcium Channel)IBA 01/2020
1	alkaline proteaseIBA 01/2020
1	Combined VaccinesIBA 01/2020
1	CalcineurinIBA 01/2020
1	CalciumIBA 01/2020
1	MycotoxinsIBA 01/2020
1	Peroxidase (Myeloperoxidase)IBA 01/2020
1	Peptide Hydrolases (Proteases)FDA Link 01/2020
1	Interleukin-6 (Interleukin 6)IBA 01/2019
1	InterferonsIBA 10/2018
1	Neurotransmitter Agents (Neurotransmitter)IBA 01/2018
1	Inactivated VaccinesIBA 01/2018
1	NF-kappa B (NF-kB)IBA 01/2018
1	A-factor (Streptomyces)IBA 01/2018
1	MannosyltransferasesIBA 01/2018
1	Aminobutyrates (Aminobutyric Acid)IBA 01/2018
1	gamma-Aminobutyric Acid (GABA)IBA 01/2018
1	Anti-Bacterial Agents (Antibiotics)IBA 12/2017
1	Oxygen (Dioxygen)IBA 01/2017
1	CXC ChemokinesIBA 01/2017
1	CopperIBA 01/2017
1	GlucansIBA 04/2016
1	LigandsIBA 01/2016
1	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 09/2015
1	Peptides (Polypeptides)IBA 01/2015
1	Interleukin-1 Receptors (Interleukin 1 Receptor)IBA 05/2014
1	Formaldehyde (Formol)FDA Link 05/2014
1	Toll-Like Receptor 2IBA 05/2014
1	Membrane Proteins (Integral Membrane Proteins)IBA 02/2014
1	Interleukin-1 (Interleukin 1)IBA 10/2013
1	LipopolysaccharidesIBA 10/2013
1	Fungal RNAIBA 07/2013
1	RNA (Ribonucleic Acid)IBA 07/2013
1	AnaphylatoxinsIBA 04/2013
1	Immunoglobulin E (IgE)IBA 04/2013
1	ChemokinesIBA 11/2011
1	Attenuated VaccinesIBA 05/2011
1	CD40 Ligand (CD40L)IBA 05/2006
1	Interleukin-10 (Interleukin 10)IBA 02/2006
1	Complement Receptors (Complement Receptor)IBA 12/2004

Therapy/Procedure

3	Therapeutics 12/2020 - 01/2007
2	Precision Medicine 01/2020 - 01/2019
2	Immunotherapy 10/2018 - 02/2006
1	Ligation 01/2021
1	Bone Marrow Transplantation (Transplantation, Bone Marrow) 12/2020
1	Drug Therapy (Chemotherapy) 12/2020